ABSTRACT
Objectives: To explore the effects and feasibility of single-port video-assisted thoracic surgery [VATS] on lobectomy for pulmonary carcinoma
Methods:A total of 67 patients were enrolled in this study, in which 21 patients were treated by single-port VATS [Sing-port Group] and 46 patients by double-port VATS [Double-port Group]. Blood loss, duration of thoracic drainage, length of post-operative hospital stay and post-operative pain ratings were compared between the two groups
Results:No significant difference existed in blood loss, duration of thoracic drainage and length of postoperative hospital stay between the two groups. However, Post-operative pain was significantly reduced in Single-port Group compared to Double-port Group
Conclusion:Single-port VATS was totally feasible with reduced post-operative pain and good looking appearance
ABSTRACT
Bronchogenic cysts are rare congenital malformation that need surgical removal. To date, bronchogenic cysts located in highest upper mediastinum excised by thoracoscopy have not been reported, though complete thoracoscopic extirpation of a bronchogenic cyst has been reported before. We excised two highest upper bronchogenic cysts by thoracoscopy successfully without any postoperative complication, demonstrating thoracoscopy could be a first-line therapeutic option even for highest upper mediastinum brochogenic cysts
ABSTRACT
To investigate effects of the limited two-port video assisted thoracic surgery on treatment of spontaneous pneumothorax. A retrospective analysis of 96 patients with spontaneous pneumothorax who underwent video assisted thoracic surgery was conducted in the present study, in which 23 cases underwent the limited two-port video assisted thoracic surgery while 73 cases treated with the standard three-port video assisted thoracic surgery or the standard two-port video assisted thoracic surgery. The mean operation time, mean intraoperative blood loss and average postoperative hospital stay, average postoperative chest tube duration and postoperative pain rating were analyzed. There was no statistical difference existed in the mean operation time, mean intraoperative blood loss, average postoperative hospital stay, average postoperative chest tube duration between the two groups [P > 0.05]. However, the postoperative pain in the limited two-port video assisted thoracic surgery group was significantly lower than that of the traditional video assisted thoracic surgery group. Compared with that of the standard three-port video assisted thoracic surgery or the standard two- port video assisted thoracic surgery, there is better cosmetic effect, and lower grade postoperative pain in the limited two-port video assisted thoracic surgery
ABSTRACT
To investigate the pharmacokinetic and bioavailability of polydatin [PD] in rats after oral and intravenous administration, a simple, rapid and sensitive liquid chromatography-tandem mass spectroscopy [LC-MS/MS] method was developed and validated for the determination of polydation. After precipitating the plasma proteins with methanol, the analytes were separated on a C[18] column [3.5 microm, 2.1×100 mm] with an isocratic mobile phase consisting of methanol-acetonitrile-0.1% formic acid [18: 15: 67, v/v/v] at a flow rate of 0.3 mL/min. The Agilent G6410A triple quadrupole LC/MS system was operated under the multiple reaction monitoring [MRM] mode and the electrospray ionization technique was in negative mode. Linear responses were obtained for PD ranging from 1.0-5000.0 ng/mL [r=0.9984] and the LLOQ was 1.0 ng/ml and was sufficient for the pharmacokinetic studies. The intra-day and inter-day accuracy and precision of the assay were less than 8.0%. The method is capable of quantifying PD. The pharmacokinetic parameters of polydatin after intragastric administration of PD with different doses [50, 100 and 300 mg/kg] and intravenous administration at the dose of 20 mg/kg, were obtained, with t[1/2] of 200.30 min, 210.30 min, 272.26 min, and 112.5 min, and AUC[0- infinity] of 125626.41 microg/L.min, 250433.47 microg/L.min, 693722.60 microg/L.min and 1723509.57 microg/L.min, respectively. The absolute bioavailability of PD was somewhat low to 2.9%. The results were firsly reported, as far as we know, about bioavailability of PD and seem important for linking PD and other phenolic glycosides-related drugs administration to their medicinal effects